Lisinopril-HCTZ Tablets (Generic Zestoretic)

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Lisinopril-HCTZ is an oral medication with a generic brand name, Zestoretic. This drug is used for treating high blood pressure. It reduces high blood pressure and helps in preventing and treating heart attacks, strokes, and kidney problems. This medicine is a combination of two active medications, viz. lisinopril and hydrochlorothiazide. Lisinopril is an Angiotensin-converting enzyme (ACE) inhibitor, which dilates the blood vessels and allows blood to flow through your blood vessels at ease. Hydrochlorothiazide is a type of diuretic (also called "water pill") that works by making your kidneys get rid of excess water and salt from your body. It also helps in controlling the blood pressure.

Lisinopril-Hydrochlorothiazide tablets are taken orally. It may be taken daily with or without food, usually once in the morning. You should take it with a considerable amount of water. If it makes you urinate frequently and you are taking it in the night, it is advisable for you to use it 4 hours before the bedtime. If you are taking medications, such as cholesterol or cholestyramine, to lower your cholesterol, take Lisinopril-HCTZ four to six hours after or before you take the medications in order to avoid any counteracting effect.

Moreover, if you are pregnant or allergic to an ACE inhibitor or sulfa drugs, you are treating diabetes or you have hereditary angioedema, do not use this medication. Do not use it with aliskiren -containing drugs.


As regards the dosage and how to safely use Lisinopril-HCTZ tablets, read the information on the prescription label that comes with the medicine and follow it. More importantly, seek advice from your doctor or pharmacist.

Side Effects

Lisinopril-Hydrochlorothiazide is accompanied by side effects. If your doctor discerns that it would be more beneficial for you to take it than not taking it due to the side effects, it may be prescribed by your doctor. Nevertheless, many patients that use it do not suffer serious side effects.

The side effects may include dizziness, tiredness, lightheadedness, headache, which may occur when you start taking the medication. The side effects may subside as your body begins to adjust to the medication. Jaundice, dry cough, little or no urination, fever, sore throat, mouth sores, dehydration, irregular heartbeats, and chills may also be observed.

Serious allergic reactions to this medication are rare. Signs of allergic reactions may include hives, breathing difficulty, severe stomach pain, swellings on the face, tongues, lips or throat.

If you observe any of these effects, instantly call your doctor or pharmacist to get an emergency medical help.


The best precaution is to let your doctor know the history of your allergy. Therefore, before you take Lisinopril-HCTZ, inform your doctor or pharmacist of your allergy to Lisinopril or hydrochlorothiazide; and other ACE inhibitors, such as benazepril and captopril.

If you also develop allergic reactions such as swellings on the face, tongues, lips or throat (due to angioedema); allergy to blood-filtering procedures such as dialysis and LDL apheresis; an allergy to wasp or bee sting, let your doctor or pharmacist know before you take this medicine. Furthermore, You need to inform your doctor or pharmacist of your health history beforehand, especially if you have kidney disease or liver disease.

This drug may cause dizziness; therefore, you should not drive or engage in any risky task while you are taking this drug. If you are taking alcohol or marijuana, you may become extremely dizzy.

The risk of lightheadedness or loss of the body water (dehydration) may become serious due to severe sweating, vomiting or diarrhea. If these conditions continue, tell your doctor or pharmacist, In order to prevent dehydration, try to drink plenty of water unless your doctor instructs you otherwise.

While you are taking this medicine, your skin may become more hyper-sensitive to the sun. Therefore, avoid direct sun, use sunscreen, wear protective clothing when you are outdoors, and avoid tanning sunlamps and booths. However, if you have sunburnt or skin blister, tell your doctor right away.

For diabetic patients, Lisinopril-HCTZ may alter their blood sugar. Therefore, if you are diabetic and you are taking this medication, ensure that you check your blood sugar regularly; or else, your doctor may need to adjust your medication. If you are pregnant, do not use this medication as it can harm your unborn baby. Pregnant women and nursing mother should consult their doctor for guidance before taking the medicine.


Some products may interact with this drug and result in worse health conditions. These products include dofetilide and aliskiren; everolimus and sirolimus that can weaken the immune system and increase the risk of infections; losartan, valsartan, and birth control pills, which may increase the level of blood potassium; lithium and sacubitril.
It may also counteract some lab tests and lead to false test results. Therefore, you will act wisely by making a list of all the drugs you use and share the list with your doctor or pharmacist.

Lisinopril-HCTZ Tablets (Generic Zestoretic)

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