The Best Time to Take Vesicare: Morning or Night

This article is about The Best Time to Take Vesicare: Morning or Night but firstly I want
to remind you Vesicare video ad.

Do you remember video ad of Vesicare? The Vesicare commercial with pipe robots and the bladder leakage metaphor used to be everywhere. This medication has been improving lives of people suffering from overactive bladder issues and interstitial cystitis for years.

Patients who are prescribed these antimuscarinic pills often ask about the best time of day to take Vesicare.

Time: when to take Morning or Night?

The major rule is to take them at the same time every day, but the intervals between doses and their number per day (1 or 2) should be determined by your doctor based on your bladder issue and your medical history. Also, there are other factors to consider when deciding on the best time of day to take Vesicare.

Time to Take Vesicare: Night?

More often than not, patients are recommended to take Vesicare before bedtime simply based on the list of side effects caused by this drug. If it brings about blurry vision and/or fatigue, you should better avoid using this medication during the day, especially if your job entails tasks that require improved focus and attention. When you use Vesicare before bedtime, these side effects will be usually gone in the morning so that you can go through your daily routine with ease.

Also, it makes more sense to use Vesicare at the end of the day for patients diagnosed with nocturia whose night sleep is disrupted several times by the urge to go to the restroom even though they might not have such issues during the day. Vesicare helps them get 7 or 8 hours of uninterrupted sleep in one go, stopping that constant pinching in their bladder that used to wake them up.

Time to Take Vesicare: Morning?

During the first days since the start of the treatment, it is advisable to use Vesicare in the morning just to find out if it causes any side effects. If you tolerate it well, it will probably have no difference which time of the day to take it. If you don’t, you can determine the right time to use it depending on the type of side effects you experience.

Time to Take Vesicare: Any time?

How can we explain the absence of specific guidance from the official manufacturer of Vesicare as to the time of administering this medication? A recent study has attempted to figure out which time of the day is better for use in people diagnosed with nocturia. All subjects were divided into two categories: the first one took solifenacin in the morning and the second one was given this medication in the evening. Surprisingly, the study proved that solifenacin brought about a significant reduction in the symptoms of overactive bladder with nocturia and improved sleep quality regardless of administration time. However, there are reasons to think that evening use might increase the drug tolerance.

For some people splitting the dose of Vesicare works better. Their symptoms of overactive bladder get eliminated or reduced when they take one pill in the morning and another before bedtime.

Vesicare: mechanism of action

Vesicare belongs to bladder antispasmodic medications. It effectively reduces bladder contractions and helps the bladder hold more urine than usual, thus giving its users control over the release of usine so that their life stops revolving around the frequent need to go to the toilet.

Vesicare: how long does it take to work?

You shouldn’t count on immediate results when starting the treatment with Vesicare. How long does it take for Vesicare to work? It might take at least a month for this medication to show its effects since it gradually builds up in your system. Fixing the internal plumbing of the human body and steadying the symptoms of overactive bladder might take some time. That’s why don’t evaluate its performance after just a few days of use unless you develop severe side effects.

As a rule, it is recommended to introduce Vesicare slowly with 5 mg dosing to prevent it from getting from one extreme to another. Some patients report having initially gotten into a pattern of about 3 days good and 3 days bad with a sudden flare up in between. As they wait, good days start beating the bad ones, and, eventually, they become  happy with the results since they stop experiencing pressure and frequency.

Drug Tolerance

As for the drug tolerance, it varies from patient to patient. Some people use it for 5 years in a row and Vesicare still effectively keeps any bladder-related discomfort at bay. Others might notice that after six months their symptoms return back again so they need to go to the doctor either to increase the dosing or choose another antimuscarinic medication to switch to. Anyway, when it comes to involuntary incontinence and other bladder problems, six month of relief is a long time.

How long does Vesicare stay in your system?

The terminal elimination half-life of Vesicare constitutes 33-85 hours, which permits once-daily use of this medication. Vesicare needs to be administered long-term to avoid all the unwanted consequences of living with overactive bladder issues, including social distancing, insomnia, physical pain, constant discomfort, and inconvenience of having to go to the loo dozens of times per day. No matter which time of the day you take Vesicare, do it consistently and avoid stopping it randomly. Once you get off this medication, you run a high risk of seeing a complete turn around. The decision to stop its use should be made only after consulting your doctor.

Is there a generic for Vesicare?

Astellas Pharma, the company that produces Vesicare, no longer holds a U.S. patent for the generic version of this medication as it expired in 2018. Teva Pharmaceutical has recently taken advantage of this. In 2019 this  announced the launch of Solifenacin Succinate, the generic for Vesicare. 

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