How to Use Chlorthalidone for the Treatment of Chronic Heart Failure

Chronic Heart Failure (CHF) is one of the leading causes of sudden death globally; it is a medical condition whereby the heart fails to pump sufficient blood required to meet the body’s tissues and organs needs. Several drugs and medications can cure chronic heart failure, but the use of Chlorthalidone has been proven to be the best preventive measure especially in hypertensive patients compared to other drugs and medications. However, it should be noted that prevention is always better than cure particularly when it comes to heart failure.

Chlorthalidone is a prescription drug or diuretic medication with the ability to combat several health conditions such as liver disease, high blood pressure, edema, and other breathing problems associated with lung failure. Chlorthalidone also helps to alleviate swelling, bone fracture, kidney stones, and improve the ability of the kidney to produce urine with high concentration.

Numerous medical conditions can be treated with Chlorthalidone; dominantly, it is used to prevent heart failures in different degrees – mild, stable or chronic. Also, Chlorthalidone is used as a medication against arterial hypertension, liver and kidney disorder, edema (fluid retention) and many more. As a diuretic drug, Chlorthalidone works by enabling the body to get rid of excess water and salt in the system. This explains why patients taking Chlorthalidone may notice frequency in their urination especially when they first begin the medication.

When combined with other drugs, Chlorthalidone is an effective drug against high blood pressure as the medicine can lower it. Chlorthalidone also increases the blood circulation by relaxing the blood vessels which enables smooth flow of blood. It exists as pale yellow, round or flat tablets with slanting edges, and comes in a dosage of 25mg or 50mg.

Chlorthalidone is a long-acting thiazide-like diuretic of the sulfamoyl benzamide class with the absence of benzothiadiazine structure. Chlorthalidone mode of the mechanism is by directly suppressing the reabsorption of sodium and chloride by the luminal membrane found in the kidney’s initial segment of distal convoluted tubule (DCT). The reaction generates an upsurge in bicarbonate, chloride, sodium, and potassium secretion causing the discharge of water. Chlorthalidone also works in inhibiting several carbonic anhydrase (CA) isoenzymes with the ability to suppress calcium and uric acid as well.

Several factors are to be considered before a doctor can prescribe Chlorthalidone for use by patients in the prevention or treatment of Chronic Heart Failure. They include the age, body weight, production stage for a woman and other health conditions. Chlorthalidone is administered in the form of oral medication. It’s advisable to take the drug at least for four hours before bedtime because as a diuretic medication, you may have to wake up several times to urinate. In a situation whereby you accidentally skip the dose, ignore it and continue with your regular schedule. In treating Chronic Heart Failure, the recommended dosage is between 25-50 mg daily which may be increased to 100mg in severe cases as advised by your physician.

However, 25-50mg/day is the lowest effective dose for maintenance. You must be careful not to overdose on Chlorthalidone and avoid the urge to continue its usage beyond the recommended time by your doctor. If after continuous use and there is no significant improvement, ACE inhibitor or digitalis or the combination of the two can be added to hasten the reaction. You must avoid the intake of alcohol after taking Chlorthalidone and also, guard against dehydration and exposure to the sunlight.

Care should be taken in using Chlorthalidone if you have a case of an impaired hepatic function or you are in an advanced stage of liver diseases because an imbalance in fluid concentration and electrolyte from thiazide diuretics may result to hepatic coma. Also, patients with severe renal disease should take caution as Chlorthalidone can lead to the precipitation of azotemia. 

Although, highly unlikely with as low as 1% report from patients. Chlorthalidone may come with effects such as decreased sexual ability, dizziness, increased sensitivity to light, loss of appetite, nausea, headache, vomiting, uneven heartbeat, easy bruising, fatigue, and vertigo.


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