Chlorthalidone and Pregnancy

Pregnancy cases differ with every person. For ones it may present problems while for others it may be a smooth sailing. One of the common problematic conditions during pregnancy is high blood pressure. Although blood pressure may rise occasionally, extremely high pressure can be harmful to both the fetus and the mother.

Chlorthalidone is a drug used to treat high blood pressure conditions during pregnancy though it has many other uses. It can also be used to prevent diseases such as kidney stones and bone fractures. Apart from high blood pressure in pregnant women, this medicine can also be used to treat, heart enlargement issues and problematic kidneys that cannot produce concentrated urine.

Although it is often combined with other drugs like enzyme blockers and receptor inhibitors, its composition makes it ideal for use as a single drug in treatment of high blood pressure. It is effective in small doses making it the best choice for those with this condition.

The left ventricle plays a crucial part in functioning of the heart since it is the main pumping chamber. It’s therefore vital that it stays healthy and works perfectly. Due to the effectiveness of Chlorthalidone in lowering blood pressure, it is the preferred medication for people with enlarged left ventricle. It reduces ventricle resistance thereby reducing the mass of the ventricle.

Chlorthalidone can reduce chances of kidney stones occurrence; it can also be used to treat a situation that has already happened. It does this by reducing the amount of calcium that is expelled through urine. This makes it a great option for people who have had multiple kidney stones attacks.

The ability of Chlorthalidone to prevent expulsion of calcium is what gives it the ability to prevent bone fractures. In addition, it promotes formation of bone minerals while encouraging differentiation of osteoblast.

Inability of kidneys to produce concentrated urine is known as nephrogenic diabetes insipidus. It occurs when the kidney fails to remove excess water from the renal tubular filtrate. Chlorthalidone changes this by preventing absorption is sodium ion thereby allowing the level of sodium to increase in the kidney.

Chlorthalidone can last in the system for up to 72 hours. It is soluble in ethanol and other compounds like DMSO. It has a wide range of effectiveness which includes prevention of carbonic anhydrase in the proximal tubule. The drug has side effects such as photo-sensitivity, headache and low mineral levels in the body among others.

Despite its effectiveness, there are many warnings that come up with regards to using this medicine during pregnancy. It is discouraged due to its many side effects even though there have not been enough proof that it can affect the fetus directly. However, there have been concerns that it can cause to both mother and child but they have need found to be reversible. Some the concerns include:

  • It can get into fetal circulation and cause imbalance.
  • Medicine’s ability to suppress milk production though this may not be a major concern for pregnant women until they give birth.
  • Chance that it can depress bone marrow in fetus as well as jaundice especially when taken closer to the due date.
  • Its ability to cause placental hypo perfusion.
  • Possibility to possibly cause neonatal thrombocytopenia.

The fact that it is a diuretic adds to the caution associated with its use. High blood pressure during pregnancy is often connected to low plasma levels. As such, using a diuretic can cause more damage than good. Therefore it is advisable to pursue alternative forms of medication that have lower chances of harming the mother and the baby. A regular use for this drug is discouraged and expectant women are advised to avoid it as much as possible.

Although Chlorthalidone doesn’t cause malformation of the fetus but it still can be harmful. The medicine can be used when potential benefits are more than the risks involved. It should be prescribed by a professional doctor and should be taken as advised. It’s important to remember that it can be transferred into milk and can therefore find its way into young ones’ systems. You should also discuss any other conditions you may have with your doctor together with any allergic reactions before you start taking the drug. Remember to follow the directions given by the doctor and discontinue use in case of adverse reactions or ineffectiveness. In case the situation worsens, discontinue use and talk to your doctor.

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