Medrol (Generic Methylprednisolone)

About Methylprednisolone

Methylprednisolone is a drug in the category of medications called corticosteroid hormone drugs. These are medicines used to provide relief and to treat symptoms such as swelling, itching, redness, and allergic reactions. As such, methylprednisolone is effective for treating diseases with these symptoms. Such disease are arthritis, blood disorder, severe allergic reaction, Asthma.

Skin disorder and immune system disorder. This list of conditions methylprednisolone can treat is not exhaustive as your doctor can prescribe Methylprednisolone for any other health condition with these symptoms. Learn more about the chemical composition of Methylprednisolone and how it works in the human body in this article.

Mechanism Of Reaction

Being in the Corticosteroids class of drugs, methylprednisolone works by regulating a class of hormones naturally produced in the adrenal gland called glucocorticoids. These hormones are necessary for maintaining good health influencing how most of the functions of the body systems.

However, malfunction of this gland may result in overproduction or underproduction of these hormones which will ultimately result in some symptoms which methylprednisolone is formulated to treat. Methylprednisolone imitates the actions of these naturally produced hormone in order react with this symptoms.

In the case of swelling or inflammation on any part of the body, methylprednisolone works by stopping the transportation of infection-fighting white blood cells (also known as polymorphonuclear leukocytes) to the inflamed part of the body. If white blood cells get to the inflamed part of the body, the cells will cluster in this area which will cause further swelling and pain in this area of the body.

This is the reason this drug is effective for swelling-related conditions such as severe allergic skin reaction, swollen joints in arthritis , inflamed breathing passage causing asthma attack, and decreasing the swelling around tumors in the body. Due to the fact that the white blood cells are rendered inactive by Methylprednisolone, a user is prone to infection which the white blood cells will normally attack.

In cases of underproduction of this hormone causing health conditions such as Addison’s disease, methylprednisolone stimulates the gland to produce more of the corticosteroids hormones for proper functioning of the body system.

Methylprednisolone also works by changing the normal immune system responses of our bodies in order to treat certain immune system conditions like aplastic anemia (A.A), Immune–Thrombocytopenia Purpura (I.T.P), Thrombotic–Thrombocytopenia Purpura (T.T.P), or hemolytic–anemia.

Dosage and Formulation

Methylprednisolone is formulated for adults and children as tablets, injectable suspension, or powder for injection. The tablet is produced in 2mg, 4mg as well as 8mg, 16mg & 32mg. The injectable suspension are available in 20mg/mL, 40 mg/mL and 80 mg/mL while the powder for injection are in 40 mg 125 mg 500mg 1g, 2g.

The dosage for methylprednisolone is as prescribed by the pharmacist or doctor, which varies depending on your symptom(s) and its severity. The dosage also varies depending on what form of the drug you are taking. Usually, you start the drug when used in tablet form with a high dosage at once and later continue with a reduced dosage at intervals per day or every other day.

Usual starting dosage is 160 mg for adult and reduced to the barest minimum depending on how the body reacts to the drug. Higher dosage of the drug is usually prescribed for injections, taken once per day or every other day.


Pharmacokinetics of methylprednisolone varies depending on the form of the drug introduced into the body.

In a study conducted by 2 pharmacologists in the US, the manner in which methylprednisolone moves in the body, and how long the drug stays in the human body was reported using 5 normal subjects. 4 subjects were given intravenous doses at 20mg, 40mg, & 80 mg each. And 20mg tablet administered as 5mg 4 times a day was given to another subject. The plasma concentration were measured at high performance thin layer (h.p.t.l.c.) and high pressure liquid chromatography (h.p.l.c.).

For all the subjects, the mean values (+/- s.d.) of half-life, mean residence time (MRT), systemic clearance (CL) and volume of distribution at steady state (Vss) of methylprednisolone following intravenous administration were 1.93 +/- 0.35 h, 3.50 +/- 1.01 h, 0.45 +/- 0.12 lh-1 kg-1 and 1.5 +/- 0.63 1 kg-1, respectively. It was also found that there were no changes to these values by dosage. The bioavailability of methylprednisolone from the 20 mg tablet was 0.82 +/- 0.11 (s.d.). In vivo hydrolysis of methylprednisolone administered intravenous was rapid with a half-life of 4.14 +/- 1.62 (s.d.) min, and was independent of dose. But in vitro hydrolysis in plasma, whole blood and red blood cells was slow; the process continuing for more than 7 days.

Drug Interaction

Prior to taking methylprednisolone, it is necessary that you inform your doctor about all medications, prescription, non-prescription or herbal, that you take. This is to prevent possible side-effect aggravation from using Methylprednisolone or reduction/termination of the potency of the drug to treat your symptoms from interaction with other medication.

Ordinarily possible serious side effects from using methylprednisolone are: increase in blood sugar level and internal bleeding. This may be worsened if Methylprednisolone is combined with drugs that can cause bleeding such as antiplatelet drugs like clopidogrel or blood thinners like warfarin or nonsteroidal anti-inflammatory drugs like Ibuprofen or aspirin.

Amongst the other drugs that could render Methylprednisolone impotent are macrolide antibiotics like erythromycin , azole antifungal drugs, HIV protease inhibitors like ritonavir, drugs for treating seizures like phenytoin.


Inform your pharmacist or doctor about any allergies or specific allergic reaction to methylprednisolone or prednisone before taking Methylprednisolone. Also inform your doctor about your medical–history, especially those connected with bleeding problems, brittle bones, blood clots, eye diseases, diabetes, heart problems, current/past infections, high blood pressure, kidney disease, mental/mood conditions, liver disease, stomach/intestinal problems and seizures.

Do not take alcohol or engage in activities that require being alert such as, driving or operating machines, while on this medication as it can cause drowsiness. Methylprednisolone sometimes causes stomach bleeding which may be aggravated if alcohol is consumed while taking the drug.

Methylprednisolone causes you to be more susceptible to infections or worsen any present infections. Therefore, always wash your hands properly to prevent the spread of infection and to avoid direct contact with people who have infections.

Always inform your doctor about long-term use of this medication in cases of emergencies and before surgery. Long-term use of this drug in a child may slow down a child's growth. So also are older adult more susceptible to suffer from brittle bones side effect of Methylprednisolone. Seek advice from your doctor before using the medication as a pregnant woman or a nursing mother.

What Is Methylprednisolone Price?

The methylprednisolone price varies depending on the brand. Generic versions of the drug which contains the active ingredient methylprednisolone are less expensive compared with the branded version such as Depo-Medrol®, A-Methapred®, and Solu-Medrol®.

You may be able to purchase methylprednisolone at a cheaper price in online stores from other countries like India or Turkey. But adding the cost of shipping will amount to the same price as in a local pharmacy.

Where To Buy Methylprednisolone?

Methylprednisolone is readily available in local pharmacies across the US. You may also buy methylprednisolone in our store.

Methylprednisolone is a very effective corticosteroid. However, Methylprednisolone should be taken with precautions and should not be abused to prevent life-threatening reaction to the drug.

+ Read more