Chlorthalidone: Mechanisms of Action
Have you or anyone in your family member got a medicine Chlorthalidone and you wondered how this medication works? We will cover this topic and describe how this medicine acts in the body after the administration. If the body is functioning in a perfect way that is well, but even minor dysfunctions in the system get disturbed running of the whole body vehicle. Therefore, it is always mandatory to find some suitable solution to get this vehicle back on the track. It is not a good way to ignore any disease or symptoms of any conditions as it involves a great risk. Keeping that in mind, first and foremost we have to know what is Chlorthalidone, so let’s begin.
Chlorthalidone is one of the well-known prevalent medication used for patients with cases like High Blood pressure’ (Hypertension), Edema ’(swelling of joints), Kidney stone, Hypoparathyroidism (low blood calcium levels), Meniere’s disease (dizziness or ringing in the ears) or Diabetes insipidus (over urination). Most of the time this drug is recommended for High Blood pressure or Edema. This medicine is classified as Diuretics’. Chlorthalidone is in the sulfamoyl benzamide class. As it lacks the benzothiadiazine structure of the thiazide-type diuretics, it is also known as a thiazide-like diuretic. it is soluble in dimethylacetamide, dimethylformamide, dimethylsulfoxide, and methanol; it is also easily soluble in warmed ethanol. As the name suggests, it helps you increase the urine to excrete extra salt and water that is accumulated in the body due to conditions caused by heart failure, kidney disease, and liver disease. In similar conditions, the medicine also helps in regulating salts and water in the body to relief Edema.
Chlorthalidone is available commercially with branding names like Thalitone and Hygroton; it comes as 25 mg and 50 mg tablet doses. Chlorthalidone is one of the most trusted medicines and. The medicine is recommended to be administered after breakfast.
The side effects of Chlorthalidone are very uncommon, however, there is a study which shows there are some effects of this medicine in case of overdose. Reported cases are low blood pressure upon standing. (Hypotension); skin irritation and skin sensitivity in sun exposure; excess sugar and uric acid in the blood; blurred vision; dizziness; muscle stiffness or weakness. Rare cases are abnormal heartbeat rate, fluid in lungs or liver damage. The dose of dopamine or norepinephrine is used to relieve the low blood pressure, is the symptoms of aftereffects does not persist after 6 hours then it’s safe to discontinue the treatment procedures.
Like any diuretic, Chlorthalidone is also banned for sportsmen. Because it reduces the weight to help the boxer or wrestler and take advantage in the lower weight competitions and masks the use of performance-enhancing drugs but making it undetectable in urine tests.
Now that we know what Chlorthalidone is, we will dive deep into its mechanisms of action and effect on the body of the patient. Let’s suppose your doctor prescribed you this drug for the high blood pressure case.
High blood pressure means the blood that is traveling through your body is exerting pressure on the walls of the blood vessels and blood capillaries. There can be many factors which cause that, but in most cases, it has the same effect. Like damaging the vital organs like heart, brain or damage to the delicate capillaries in the body, to prevent the damage, some action is needed to reduce the pressure in the blood and here Chlorthalidone plays are a role.
The diuretic nature of this machine comes in handy. After the consumption of this drug your body start making urine by adding more water and salt to the blood and trigger the kidney’s filter into action. Chlorthalidone induces salt in the blood by reducing the reabsorption of sodium and chloride through the kidney in normal circumstances. By lowering the amount of fluid from the blood, it reduces the blood pressure effectively. Chlorthalidone also helps in de-tightening if the blood vessels to increase the smooth flow of blood through vessels.
Chlorthalidone is used for reducing high blood pressure since the 1960s. It is approved by FDA as a safe medical consumption under the dose range of 25 mg to 100 mg.