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What is Mesalamine
Mesalamine is an anti-inflammatory drug which has been used in the treatment of Ulcerative colitis and other inflammatory conditions in the body. Mesalamine reduces effects of ulcerative colitis such as bleeding in the rectum, passing of watery stool and pain in the stomach. Other Names include: Asacol HD, 5-ASA, mesalazine, Pentasa, Delzicol, Lialda, Apriso Class Mesalamine is in a class of drugs known as 5-Aminosalicylic Acid Derivatives. Other drugs in this class are olsalazine, Asacol HD, Dipentum, Giazo, Lialda, and sulfasalazine.Mode of Action Mesalamine acts to curb prostaglandin release which causes inflammation of cells. It also blocks leukotriene synthesis and releases in the large intestines. 5- aminosalicylic acid is the active component in Mesalamine.
Once taken, the immediate release form of Mesalamine is absorbed rapidly while the extended release mesalamine has a 25% bioavailability rate. Improvement noted in the colon after taking the drug is usually after 7 days to approximately three months. Mesalamine reaches peak plasma levels in 4hrs (apriso), pentasa takes 3 hrs, Mezavant takes 8 hrs while Asacol HD takes approximately 13 hrs. 5- ASA binds to blood protein albumin at 43% while N-Acetyl-5-ASA binds at 78%. Unlike other drugs that go through the hepatic system alone, mesalamine is metabolized partially in the colon. Mesalamine acetylated in the large intestine wall and the hepatic system to form a metabolite in the inactive form which is N-acetyl-5-aminosalicylic acid. The half-life of the active form 5-ASA is 1-9 hrs while that of the inactive form N-acetyl-5-aminosalicylic acid is 3-16hrs. The majority of Mesalamine is later eliminated through the biliary duct at 72% and some of it through the urine (20-30%)
How To Use And Dosage
Dosage For Ulcerative Colitis 160 mg TDS orally when taking Asacol HD0.8g TDS orally when taking Delzicol 240 mg – 480 mg orally for up to 8 weeks once daily when taking Lialda 100 mg four times a day orally when taking Pentasa. This should be taken for 8 weeks.To prevent remission or reoccurrence of the Ulcerative colitis, it is recommended that mesalamine tablets be taken as follows 150 mg of Apriso orally daily 160 mg per day orally of Delzicol 160 mg per day orally of Asacol HD 240 mg of Lialda orally daily with food.100 mg of Pentasa orally four times daily for 8 weeks.
How do you take Mesalamine?
As directed by your doctor, take this medication orally usually its taken 3 or 4 times on a daily basis. Mesalamine capsule can be taken with meals or without while the mesalamine tablet is taken strictly with food. When taking Mesalamine, do not try to chew or crush it with your teeth while in the mouth instead, swallow it as a whole. In doing so, Mesalamine is able to arrive at the colon safely where it is acetylated.The dosage of Mesalamine might not be the same for all the patients. Your doctor might tailor the medication dosage according to your condition or response to treatment. To get satisfying results, take this medication on a regular basis so as to benefit from it.
Some minor side effects might be noted when taking Mesalamine. Not all though and still, they are not supposed to be worse to an extent that they affect your activities daily living. In case they reach to such a point, consult your doctor/ pharmacist. They include General body ache and discomfort, drowsiness, flatulence, severe headache, acne, abdominal pain, renal impairment, change of urine color, cholestatic hepatitis, nausea, hypertension, pain in the joints, distention of the abdomen, hepatic failure, mesalamine-induced acute intolerance syndrome, loss of hair, inflammation around the heart muscles (pericarditis), rectal polyps among many others.
In case you are or have an allergy to mesalamine, you should not take the other precursors such as Pentasa, Apriso, Lialda among others since they all contain the ingredient mesalamine. Always seek your doctor or pharmacist prior to use to take a brief history and note if you are allergic to any of the ingredients. However, if you note any unusual signs, seek medical review from your doctor. Mesalamine is a 5-ASA and should be put out of reach of children. It is a drug that is highly susceptible to overdose and thus children or Alzheimer’s or mentally ill people shouldn’t be close to it.It is contraindicated to anyone who has an allergy to salicylates such as aspirin among others.Mothers who are breastfeeding are not allowed to take Mesalamine since it transverses to breastmilk and might have effects on the child.Those with chicken pox, or varicella-like or flu-like symptoms shouldn’t take Mesalamine. It might worsen the condition they have.People who have renal impairment shouldn’t take Mesalamine since it might not be eliminated as supposed. Thus other drugs might be used.People with coagulation abnormalities or on drugs such as warfarin should take this drug with caution since it might worsen the condition leading to comorbidities.Pericarditis is a rare side effect but should be monitored. If you note any dyspnea or pain around the chest area, seek medical review. Men who take Mesalamine have shown low sperm count while those patients with liver insufficiency worsen to liver failure.
Just as any other medication, some drugs affect the distribution of Mesalamine in the body. It is important to know these drugs so that by no chance will you take them concomitantly. These drugs include: Most of the drugs under the class proton pump inhibitors such as omeprazole, esomeprazole, lansoprazole, pantoprazole, rabeprazole, and dexlansoprazole have very serious interaction with mesalamine. Other drug interactions include ranitidine, nizatidine, vaccines such as the measles vaccine, mumps, rubella, and the varicella vaccine. These are not the only drugs that interact with mesalamine. Therefore, it is very important to be cautious with any drug that you will be taking concomitantly with. Always consult your doctor or pharmacist when mixing or taking drugs together.
Mesalamine price is not that costly as compared to most antiviral drugs. It is the cheapest anti-antiviral drug available. You can buy Mesalamine online on various sites which are accredited to sell drugs through their websites such as FairPriceRX.com