Alphagan (Generic Brimonidine Tartrate)


Brimonidine tartrate, commonly known as Alphagan P is a drug used to treat high fluid in eyes or open-angle glaucoma. A high fluid pressure in the eye can cause nerve damage, vision loss or even blindness. This medicine reduces pressure by enhancing fluid drainage in the eye and also by reducing fluid formation in the eye.

Usage of brimonidine tartrate solution

Wash your hands before applying for Brimonidine tartrate. Don't touch the tip of the dropper or allow it to touch your eye or any surface since it can cause contamination. Those that use contact lenses should put on their lenses 15 minutes after applying this medication. This is because brimonidine contains benzalkonium chloride which can cause eye irritation.

Look upward and make a pouch by pulling down the lower eyelid. Hold the dropper over the eye and let the medicine drop directly to the eye. Look down and close your eyes gently for 2 minutes. Gently apply pressure on the corner of your eye using your finger. Avoid blinking or rubbing your eye since it can prevent the medicine from draining out. Repeat the procedure on the eye if your pharmacist directed you to do so.

Do not wash the dropper. Replace the cap after use. In case you are using other types of eye medicines, wait for over five minutes before applying them. It is advisable to use eye drops before eye ointments.

Apply for this medicine on a regular basis for it to work well. Continue applying brimonidine tartrate even if you don’t experience any symptoms. Remember to apply brimonidine at the same time daily. Consult your doctor before you stop using it. Also, contact your physician in case your condition worsens.


Apply one drop of brimonidine tartrate three times a day. Ask your physician for more details. Don't swallow or share Brimonidine tartrate.

In case you miss a dosage, apply the medication as soon as you remember. Don't double dose if you miss a dose.

Side effects

Note that your doctor can only prescribe this medicine if he knows that its benefit outweighs the risks. Majority of people using Brimonidine tartrate do not experience serious side effects.

The following are the common side effects of brimonidine tartrate solution:

  • Blurred vision
  • Eye itching, redness, and discomfort
  • Dry mouth
  • Dizziness
  • Bad taste
  • Fatigue
  • Drowsiness

Notify your doctor immediately if any of these symptoms persist.

The following side effects are unlikely, but you should contact your doctor immediately if you experience them.

  • Fast heartbeats
  • Eye pain, swelling or burning
  • Vision changes
  • Increased sensitivity to light

Serious side effects include:

  • Fainting
  • Slow or irregular heartbeats

Serious allergic reactions are unlikely but seek medical attention promptly if you experience them. Serious allergic reactions include rashes, breathing troubles, dizziness and swelling in the face, throat or tongue.

Seek medical advice in case you experience any other side effects.

Medical and laboratory tests such as measuring intraocular pressure should be performed regularly to monitor progress and also to check for side effects.


Brimonidine tartrate interactions can cause serious side effects or change how medicines work. Tell your doctor all the medicines that you are using. Some of the products that can interact with brimonidine tartrate solution include Beta blockers such as metoprolol, atenolol, and timolol eye drops. Others include high blood pressure drugs such as clonidine, digoxin and also tricyclic antidepressants like amitriptyline.

Notify your doctor if you are using drugs that can cause drowsiness. Some of these products are cough relievers (such as hydrocodone and codeine), marijuana, alcohol, drugs for anxiety and sleep (such as zolpidem, lorazepam, alprazolam), muscle relaxants like cyclobenzaprine and antihistamines such diphenhydramine and cetirizine.

There is no exact information on possible interactions of brimonidine with drugs that can affect metabolism. However, caution is advised when brimonidine is used on patients who are using medications that can affect uptake of circulating amines and metabolism. They include reserpine, chlorpromazine, and methylphenidate.

Brimonidine tartrate can cause a decrease in blood pressure in some patients. It is therefore important to be cautious when using medications such as cardiac glycosides and anti-hypersensitive.

You should read the labels of all your drugs since they may contain products that cause drowsiness. Always consult your doctor on how to safely use those products.


Brimonidine tartrate should not be used for children who are less than two years old. Those aged 2 to 7 years should be treated with caution. They should be monitored closely since this medication can cause somnolence. Children are more vulnerable to its side effects. Caution should be taken when treating people with the following diseases:

  • Unstable, severe and uncontrolled heart diseases.
  • Coronary or cerebral insufficiency
  • Orthostatic hypotension
  • Raynaud’s phenomenon
  • Thromboangiitis obliterans
  • Renal and hepatic impairment

Tell your pharmacist if you are allergic to this medication, apraclonidine or any other allergies. It may also inactive components that may cause allergic reactions or other conditions. Talk to your doctor for more information.

Fertility, lactation, and pregnancy: Brimonidine tartrate can cause postnatal growth reduction and increased preimplantation. It is unknown if this medicine can be passed into breast milk. Consult your physician before breastfeeding. This medication can only be used during pregnancy if the benefits outweigh the risks on both the mother and fetus. Brimonidine should not be used by mothers nursing infants.

Brimonidine drops should be used when using machines or driving since it may cause fatigue or drowsiness. It may also cause abnormal or blurred vision which can affect the ability to operate machines or drive especially at night. Limit alcoholic drinks and marijuana since they can make you more drowsy and dizzy.

Where to buy brimonidine tartrate

You can order brimonidine tartrate solution online or buy it from pharmacies.

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